I love Python and have posted a number of Python tips on this blog. And I've been involved in the creation of sizable web sites using Django.
But I've come to feel that for many types of web sites, doing all the rendering on the server and shipping the rendered page to the browser is probably not be the best way to go. Certainly, I'm not the first to come to that conclusion. Google Docs is a phenomenal example of what can be done in a "single page app" (SPA) rendered in the browser. There are many others.
Eliminating such overhead seems like it could be very helpful for my goal of creating my next project entirely by myself.
You can put together tools such as Firebase, Knockout and KnockoutFire to cause changes in your database to automatically and near-instantaneously show up on-screen in your SPA with trivially little code through data-binding. Of course, there are ways of doing that with a framework like Django as well, but data-binding is integral to the way some SPA frameworks operate.
Lately I've been experimenting with Durandal as my SPA framework. It incorporates Knockout, and I'm using KnockoutFire to connect it to a Firebase database. Using a framework like Durandal provides organization for your code, and provides facilities like routing.